Asthma and influenza vaccination in elderly hospitalized patients: Matched case-control study in Spain.
Identifieur interne : 000077 ( Main/Exploration ); précédent : 000076; suivant : 000078Asthma and influenza vaccination in elderly hospitalized patients: Matched case-control study in Spain.
Auteurs : María Morales Suárez-Varela [Espagne] ; Agustin Llopis [Espagne] ; Estrella Fernandez-Fabrellas [Espagne] ; Francisco Sanz [Espagne] ; M Jose Perez-Lozano [Espagne] ; Vicente Martin [Espagne] ; Jenaro Astray [Espagne] ; Jesús Castilla [Espagne] ; Mikel Egurrola [Espagne] ; Luis Force [Espagne] ; Diana Toledo [Espagne] ; Àngela Domínguez [Espagne]Source :
- The Journal of asthma : official journal of the Association for the Care of Asthma [ 1532-4303 ] ; 2018.
Descripteurs français
- KwdFr :
- Asthme (épidémiologie), Espagne (épidémiologie), Femelle (MeSH), Grippe humaine (prévention et contrôle), Grippe humaine (épidémiologie), Hospitalisation (MeSH), Humains (MeSH), Mâle (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Vaccination (statistiques et données numériques), Vaccins antigrippaux (administration et posologie), Études cas-témoins (MeSH).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- prévention et contrôle : Grippe humaine.
- statistiques et données numériques : Vaccination.
- épidémiologie : Asthme, Espagne, Grippe humaine.
- Femelle, Hospitalisation, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- Aged (MeSH), Aged, 80 and over (MeSH), Asthma (epidemiology), Case-Control Studies (MeSH), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Influenza Vaccines (administration & dosage), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Male (MeSH), Spain (epidemiology), Vaccination (statistics & numerical data).
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- geographic , epidemiology : Spain.
- epidemiology : Asthma, Influenza, Human.
- prevention & control : Influenza, Human.
- statistics & numerical data : Vaccination.
- Aged, Aged, 80 and over, Case-Control Studies, Female, Hospitalization, Humans, Male.
Abstract
OBJECTIVES
Influenza infection is an exacerbating factor for asthma, and its prevention is critical in managing asthmatic patients. We investigated the effect of influenza vaccination on asthmatic and non-asthmatic patients hospitalized with laboratory-confirmed influenza in Spain.
METHODS
We made a matched case-control study to assess the frequency of hospitalization for influenza in people aged ≥65 years. Hospitalized patients with unplanned hospital admissions were recruited from 20 hospitals representing seven Spanish regions. Cases were defined as those hospitalized due to a laboratory-confirmed influenza infection and controls were matched by age, sex, and hospital. Data were obtained from clinical records, and patients stratified by clinical asthma history. Vaccination status and asthma due to influenza infection were analyzed according to sociodemographic variables and medical risk conditions. Multivariable analysis was made using conditional logistic regression models.
RESULTS
582 hospitalized patients with influenza (15.8% asthmatic) and 1,570 hospitalized patients without influenza (7.9% asthmatic) were included. In the multivariable conditional logistic regression using unvaccinated and non-asthmatic patients as the reference group, vaccination significantly prevented influenza in non-asthmatic patients (aOR = 0.63; 95% CI: 0.45, 0.88) and also showed a trend for a possibly protective effect in asthmatic patients (aOR = 0.79; 95% CI: 0.34, 1.81).
CONCLUSION
Our results suggest that influenza vaccination could be a protective factor for asthmatic patients, although the results are inconclusive and further research is required. Practically, given the better clinical evolution of vaccinated asthma cases, and the lack of better evidence, the emphasis on vaccination of this group should continue.
DOI: 10.1080/02770903.2017.1332204
PubMed: 28636411
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Fernandez-Fabrellas</name><affiliation wicri:level="1"><nlm:affiliation>d Hospital General Universitario , Valencia , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>d Hospital General Universitario , Valencia </wicri:regionArea><wicri:noRegion>Valencia </wicri:noRegion></affiliation></author><author><name sortKey="Sanz, Francisco" sort="Sanz, Francisco" uniqKey="Sanz F" first="Francisco" last="Sanz">Francisco Sanz</name><affiliation wicri:level="1"><nlm:affiliation>d Hospital General Universitario , Valencia , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>d Hospital General Universitario , Valencia </wicri:regionArea><wicri:noRegion>Valencia </wicri:noRegion></affiliation></author><author><name sortKey="Perez Lozano, M Jose" sort="Perez Lozano, M Jose" uniqKey="Perez Lozano M" first="M Jose" last="Perez-Lozano">M Jose Perez-Lozano</name><affiliation wicri:level="1"><nlm:affiliation>e Servicio de Medicina Preventiva , Hospital Universitario del Valme , Sevilla, Andalucia , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>e Servicio de Medicina Preventiva , Hospital Universitario del Valme , Sevilla, Andalucia </wicri:regionArea><wicri:noRegion>Andalucia </wicri:noRegion></affiliation></author><author><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martin">Vicente Martin</name><affiliation wicri:level="1"><nlm:affiliation>f Área de Medicina Preventiva y Salud Publica, Departamento de Ciencias Biomédicas , Universidad de León , León , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>f Área de Medicina Preventiva y Salud Publica, Departamento de Ciencias Biomédicas , Universidad de León , León </wicri:regionArea><wicri:noRegion>León </wicri:noRegion></affiliation></author><author><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><affiliation wicri:level="1"><nlm:affiliation>g Subdirección General de Epidemiologia de la Comunidad de Madrid , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>g Subdirección General de Epidemiologia de la Comunidad de Madrid , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation></author><author><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><affiliation wicri:level="1"><nlm:affiliation>h Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Recinto de Complejo Hospitalario de Navarra C/Irunlarrea , Pamplona, Navarra , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>h Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Recinto de Complejo Hospitalario de Navarra C/Irunlarrea , Pamplona, Navarra </wicri:regionArea><wicri:noRegion>Navarra </wicri:noRegion></affiliation></author><author><name sortKey="Egurrola, Mikel" sort="Egurrola, Mikel" uniqKey="Egurrola M" first="Mikel" last="Egurrola">Mikel Egurrola</name><affiliation wicri:level="1"><nlm:affiliation>i Servicio de Inmunología , Hospital de Galdakao-Usansolo , Usansolo, Vizcaya , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>i Servicio de Inmunología , Hospital de Galdakao-Usansolo , Usansolo, Vizcaya </wicri:regionArea><wicri:noRegion>Vizcaya </wicri:noRegion></affiliation></author><author><name sortKey="Force, Luis" sort="Force, Luis" uniqKey="Force L" first="Luis" last="Force">Luis Force</name><affiliation wicri:level="1"><nlm:affiliation>j Hospital de Mataró , Mataró, Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>j Hospital de Mataró , Mataró, Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author><author><name sortKey="Toledo, Diana" sort="Toledo, Diana" uniqKey="Toledo D" first="Diana" last="Toledo">Diana Toledo</name><affiliation wicri:level="1"><nlm:affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author><author><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Àngela" last="Domínguez">Àngela Domínguez</name><affiliation wicri:level="1"><nlm:affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:28636411</idno><idno type="pmid">28636411</idno><idno type="doi">10.1080/02770903.2017.1332204</idno><idno type="wicri:Area/Main/Corpus">00090</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00090</idno><idno 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</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Centro Superior de Investigación en Salud Pública (CSISP) , Valencia , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>c Centro Superior de Investigación en Salud Pública (CSISP) , Valencia </wicri:regionArea><wicri:noRegion>Valencia </wicri:noRegion></affiliation></author><author><name sortKey="Llopis, Agustin" sort="Llopis, Agustin" uniqKey="Llopis A" first="Agustin" last="Llopis">Agustin Llopis</name><affiliation wicri:level="1"><nlm:affiliation>a Área de Medicina Preventiva y Salud Publica, Departamento de Medicina Preventiva , Universidad de Valencia , Burjasot, Valencia , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>a Área de Medicina Preventiva y Salud Publica, Departamento de Medicina Preventiva , Universidad de Valencia , Burjasot, Valencia </wicri:regionArea><wicri:noRegion>Valencia </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Centro Superior de Investigación en Salud Pública (CSISP) , Valencia , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>c Centro Superior de Investigación en Salud Pública (CSISP) , Valencia </wicri:regionArea><wicri:noRegion>Valencia </wicri:noRegion></affiliation></author><author><name sortKey="Fernandez Fabrellas, Estrella" sort="Fernandez Fabrellas, Estrella" uniqKey="Fernandez Fabrellas E" first="Estrella" last="Fernandez-Fabrellas">Estrella Fernandez-Fabrellas</name><affiliation wicri:level="1"><nlm:affiliation>d Hospital General Universitario , Valencia , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>d Hospital General Universitario , Valencia </wicri:regionArea><wicri:noRegion>Valencia </wicri:noRegion></affiliation></author><author><name sortKey="Sanz, Francisco" sort="Sanz, Francisco" uniqKey="Sanz F" first="Francisco" last="Sanz">Francisco Sanz</name><affiliation wicri:level="1"><nlm:affiliation>d Hospital General Universitario , Valencia , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>d Hospital General Universitario , Valencia </wicri:regionArea><wicri:noRegion>Valencia </wicri:noRegion></affiliation></author><author><name sortKey="Perez Lozano, M Jose" sort="Perez Lozano, M Jose" uniqKey="Perez Lozano M" first="M Jose" last="Perez-Lozano">M Jose Perez-Lozano</name><affiliation wicri:level="1"><nlm:affiliation>e Servicio de Medicina Preventiva , Hospital Universitario del Valme , Sevilla, Andalucia , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>e Servicio de Medicina Preventiva , Hospital Universitario del Valme , Sevilla, Andalucia </wicri:regionArea><wicri:noRegion>Andalucia </wicri:noRegion></affiliation></author><author><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martin">Vicente Martin</name><affiliation wicri:level="1"><nlm:affiliation>f Área de Medicina Preventiva y Salud Publica, Departamento de Ciencias Biomédicas , Universidad de León , León , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>f Área de Medicina Preventiva y Salud Publica, Departamento de Ciencias Biomédicas , Universidad de León , León </wicri:regionArea><wicri:noRegion>León </wicri:noRegion></affiliation></author><author><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><affiliation wicri:level="1"><nlm:affiliation>g Subdirección General de Epidemiologia de la Comunidad de Madrid , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>g Subdirección General de Epidemiologia de la Comunidad de Madrid , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation></author><author><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><affiliation wicri:level="1"><nlm:affiliation>h Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Recinto de Complejo Hospitalario de Navarra C/Irunlarrea , Pamplona, Navarra , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>h Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Recinto de Complejo Hospitalario de Navarra C/Irunlarrea , Pamplona, Navarra </wicri:regionArea><wicri:noRegion>Navarra </wicri:noRegion></affiliation></author><author><name sortKey="Egurrola, Mikel" sort="Egurrola, Mikel" uniqKey="Egurrola M" first="Mikel" last="Egurrola">Mikel Egurrola</name><affiliation wicri:level="1"><nlm:affiliation>i Servicio de Inmunología , Hospital de Galdakao-Usansolo , Usansolo, Vizcaya , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>i Servicio de Inmunología , Hospital de Galdakao-Usansolo , Usansolo, Vizcaya </wicri:regionArea><wicri:noRegion>Vizcaya </wicri:noRegion></affiliation></author><author><name sortKey="Force, Luis" sort="Force, Luis" uniqKey="Force L" first="Luis" last="Force">Luis Force</name><affiliation wicri:level="1"><nlm:affiliation>j Hospital de Mataró , Mataró, Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>j Hospital de Mataró , Mataró, Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author><author><name sortKey="Toledo, Diana" sort="Toledo, Diana" uniqKey="Toledo D" first="Diana" last="Toledo">Diana Toledo</name><affiliation wicri:level="1"><nlm:affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author><author><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Àngela" last="Domínguez">Àngela Domínguez</name><affiliation wicri:level="1"><nlm:affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid </wicri:regionArea><wicri:noRegion>Madrid </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona , Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona </wicri:regionArea><wicri:noRegion>Barcelona </wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of asthma : official journal of the Association for the Care of Asthma</title><idno type="eISSN">1532-4303</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Asthma (epidemiology)</term><term>Case-Control Studies (MeSH)</term><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (prevention & control)</term><term>Male (MeSH)</term><term>Spain (epidemiology)</term><term>Vaccination (statistics & numerical data)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Asthme (épidémiologie)</term><term>Espagne (épidémiologie)</term><term>Femelle (MeSH)</term><term>Grippe humaine (prévention et contrôle)</term><term>Grippe humaine (épidémiologie)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Mâle (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Vaccination (statistiques et données numériques)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Asthma</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Vaccination</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Asthme</term><term>Espagne</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>Influenza infection is an exacerbating factor for asthma, and its prevention is critical in managing asthmatic patients. We investigated the effect of influenza vaccination on asthmatic and non-asthmatic patients hospitalized with laboratory-confirmed influenza in Spain.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We made a matched case-control study to assess the frequency of hospitalization for influenza in people aged ≥65 years. Hospitalized patients with unplanned hospital admissions were recruited from 20 hospitals representing seven Spanish regions. Cases were defined as those hospitalized due to a laboratory-confirmed influenza infection and controls were matched by age, sex, and hospital. Data were obtained from clinical records, and patients stratified by clinical asthma history. Vaccination status and asthma due to influenza infection were analyzed according to sociodemographic variables and medical risk conditions. Multivariable analysis was made using conditional logistic regression models.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>582 hospitalized patients with influenza (15.8% asthmatic) and 1,570 hospitalized patients without influenza (7.9% asthmatic) were included. In the multivariable conditional logistic regression using unvaccinated and non-asthmatic patients as the reference group, vaccination significantly prevented influenza in non-asthmatic patients (aOR = 0.63; 95% CI: 0.45, 0.88) and also showed a trend for a possibly protective effect in asthmatic patients (aOR = 0.79; 95% CI: 0.34, 1.81).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Our results suggest that influenza vaccination could be a protective factor for asthmatic patients, although the results are inconclusive and further research is required. Practically, given the better clinical evolution of vaccinated asthma cases, and the lack of better evidence, the emphasis on vaccination of this group should continue.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28636411</PMID><DateCompleted><Year>2019</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2019</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-4303</ISSN><JournalIssue CitedMedium="Internet"><Volume>55</Volume><Issue>4</Issue><PubDate><Year>2018</Year><Month>04</Month></PubDate></JournalIssue><Title>The Journal of asthma : official journal of the Association for the Care of Asthma</Title><ISOAbbreviation>J Asthma</ISOAbbreviation></Journal><ArticleTitle>Asthma and influenza vaccination in elderly hospitalized patients: Matched case-control study in Spain.</ArticleTitle><Pagination><MedlinePgn>391-401</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/02770903.2017.1332204</ELocationID><Abstract><AbstractText Label="OBJECTIVES">Influenza infection is an exacerbating factor for asthma, and its prevention is critical in managing asthmatic patients. We investigated the effect of influenza vaccination on asthmatic and non-asthmatic patients hospitalized with laboratory-confirmed influenza in Spain.</AbstractText><AbstractText Label="METHODS">We made a matched case-control study to assess the frequency of hospitalization for influenza in people aged ≥65 years. Hospitalized patients with unplanned hospital admissions were recruited from 20 hospitals representing seven Spanish regions. Cases were defined as those hospitalized due to a laboratory-confirmed influenza infection and controls were matched by age, sex, and hospital. Data were obtained from clinical records, and patients stratified by clinical asthma history. Vaccination status and asthma due to influenza infection were analyzed according to sociodemographic variables and medical risk conditions. Multivariable analysis was made using conditional logistic regression models.</AbstractText><AbstractText Label="RESULTS">582 hospitalized patients with influenza (15.8% asthmatic) and 1,570 hospitalized patients without influenza (7.9% asthmatic) were included. In the multivariable conditional logistic regression using unvaccinated and non-asthmatic patients as the reference group, vaccination significantly prevented influenza in non-asthmatic patients (aOR = 0.63; 95% CI: 0.45, 0.88) and also showed a trend for a possibly protective effect in asthmatic patients (aOR = 0.79; 95% CI: 0.34, 1.81).</AbstractText><AbstractText Label="CONCLUSION">Our results suggest that influenza vaccination could be a protective factor for asthmatic patients, although the results are inconclusive and further research is required. Practically, given the better clinical evolution of vaccinated asthma cases, and the lack of better evidence, the emphasis on vaccination of this group should continue.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Suárez-Varela</LastName><ForeName>María Morales</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>a Área de Medicina Preventiva y Salud Publica, Departamento de Medicina Preventiva , Universidad de Valencia , Burjasot, Valencia , Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c Centro Superior de Investigación en Salud Pública (CSISP) , Valencia , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Llopis</LastName><ForeName>Agustin</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>a Área de Medicina Preventiva y Salud Publica, Departamento de Medicina Preventiva , Universidad de Valencia , Burjasot, Valencia , Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c Centro Superior de Investigación en Salud Pública (CSISP) , Valencia , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez-Fabrellas</LastName><ForeName>Estrella</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>d Hospital General Universitario , Valencia , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanz</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>d Hospital General Universitario , Valencia , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perez-Lozano</LastName><ForeName>M Jose</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>e Servicio de Medicina Preventiva , Hospital Universitario del Valme , Sevilla, Andalucia , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Vicente</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>f Área de Medicina Preventiva y Salud Publica, Departamento de Ciencias Biomédicas , Universidad de León , León , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Astray</LastName><ForeName>Jenaro</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>g Subdirección General de Epidemiologia de la Comunidad de Madrid , Madrid , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castilla</LastName><ForeName>Jesús</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>h Instituto de Investigación Sanitaria de Navarra (IdiSNA) , Recinto de Complejo Hospitalario de Navarra C/Irunlarrea , Pamplona, Navarra , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Egurrola</LastName><ForeName>Mikel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>i Servicio de Inmunología , Hospital de Galdakao-Usansolo , Usansolo, Vizcaya , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Force</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>j Hospital de Mataró , Mataró, Barcelona , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Toledo</LastName><ForeName>Diana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Domínguez</LastName><ForeName>Àngela</ForeName><Initials>À</Initials><Identifier Source="ORCID">0000-0003-0219-1907</Identifier><AffiliationInfo><Affiliation>b CIBER en Epidemiologia y Salud Pública (CIBERESP) , Madrid , Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>k Departamento de Salud Pública , Universidad de Barcelona , Barcelona , Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Working group of project pi12/02079 ‘effectiveness of influenza and pneumococcal polysaccharide 23-valent vaccines in people aged 65 years and more’</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>06</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Asthma</MedlineTA><NlmUniqueID>8106454</NlmUniqueID><ISSNLinking>0277-0903</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Asthma</Keyword><Keyword MajorTopicYN="Y">asthma management</Keyword><Keyword MajorTopicYN="Y">elderly</Keyword><Keyword MajorTopicYN="Y">influenza</Keyword><Keyword MajorTopicYN="Y">influenza-related hospitalization</Keyword><Keyword MajorTopicYN="Y">laboratory-confirmed influenza</Keyword><Keyword MajorTopicYN="Y">multivariable conditional logistic regression</Keyword><Keyword MajorTopicYN="Y">prevention</Keyword><Keyword MajorTopicYN="Y">protective factor</Keyword><Keyword MajorTopicYN="Y">vaccination</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>3</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28636411</ArticleId><ArticleId IdType="doi">10.1080/02770903.2017.1332204</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li></country></list><tree><country name="Espagne"><noRegion><name sortKey="Suarez Varela, Maria Morales" sort="Suarez Varela, Maria Morales" uniqKey="Suarez Varela M" first="María Morales" last="Suárez-Varela">María Morales Suárez-Varela</name></noRegion><name sortKey="Astray, Jenaro" sort="Astray, Jenaro" uniqKey="Astray J" first="Jenaro" last="Astray">Jenaro Astray</name><name sortKey="Castilla, Jesus" sort="Castilla, Jesus" uniqKey="Castilla J" first="Jesús" last="Castilla">Jesús Castilla</name><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Àngela" last="Domínguez">Àngela Domínguez</name><name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Àngela" last="Domínguez">Àngela Domínguez</name><name sortKey="Egurrola, Mikel" sort="Egurrola, Mikel" uniqKey="Egurrola M" first="Mikel" last="Egurrola">Mikel Egurrola</name><name sortKey="Fernandez Fabrellas, Estrella" sort="Fernandez Fabrellas, Estrella" uniqKey="Fernandez Fabrellas E" first="Estrella" last="Fernandez-Fabrellas">Estrella Fernandez-Fabrellas</name><name sortKey="Force, Luis" sort="Force, Luis" uniqKey="Force L" first="Luis" last="Force">Luis Force</name><name sortKey="Llopis, Agustin" sort="Llopis, Agustin" uniqKey="Llopis A" first="Agustin" last="Llopis">Agustin Llopis</name><name sortKey="Llopis, Agustin" sort="Llopis, Agustin" uniqKey="Llopis A" first="Agustin" last="Llopis">Agustin Llopis</name><name sortKey="Llopis, Agustin" sort="Llopis, Agustin" uniqKey="Llopis A" first="Agustin" last="Llopis">Agustin Llopis</name><name sortKey="Martin, Vicente" sort="Martin, Vicente" uniqKey="Martin V" first="Vicente" last="Martin">Vicente Martin</name><name sortKey="Perez Lozano, M Jose" sort="Perez Lozano, M Jose" uniqKey="Perez Lozano M" first="M Jose" last="Perez-Lozano">M Jose Perez-Lozano</name><name sortKey="Sanz, Francisco" sort="Sanz, Francisco" uniqKey="Sanz F" first="Francisco" last="Sanz">Francisco Sanz</name><name sortKey="Suarez Varela, Maria Morales" sort="Suarez Varela, Maria Morales" uniqKey="Suarez Varela M" first="María Morales" last="Suárez-Varela">María Morales Suárez-Varela</name><name sortKey="Suarez Varela, Maria Morales" sort="Suarez Varela, Maria Morales" uniqKey="Suarez Varela M" first="María Morales" last="Suárez-Varela">María Morales Suárez-Varela</name><name sortKey="Toledo, Diana" sort="Toledo, Diana" uniqKey="Toledo D" first="Diana" last="Toledo">Diana Toledo</name><name sortKey="Toledo, 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